Dr Chalmers Path to Pro - Retatrutide (GLP-1, GIP, Glucagon)
Retatrutide is a new peptide that works on three key pathways at once GLP-1, GIP and glucagon. This combined action may help with blood sugar control, fat use, and reducing excess liver fat. Early signs suggest it could be useful for improving weight management and overall metabolic health.
Because it can speed up how the body uses energy, it’s important to monitor things like protein intake, vitamins, minerals, and blood sugar levels. Gradual dose changes and good nutrition can help reduce side effects and support healthy muscle, hormone, and liver function while using it.
Highlights of the Podcast
00:01 - Introduction to Retatrutide
01:39 – Visible Changes & Mechanism of Action
03:21 – Hyperglycemia Risk & Protein Needs
04:38 – Digestive Effects & Liver Support
06:59 – Diabetes, Insulin Sensitivity & Dementia Potential
09:46 – Heart Rate & Monitoring
11:10 – Nutrient & Hormone Support
13:31 – Future Research & Muscle Health
15:57 – Cost, Access & Dosing Strategy
Dr. Matt Chalmers [00:00:03] All right, so let’s go to the retitruotide. This is one of the newer peptides, it is a, it’s like the next generation of, or the next iteration of GLP-1s. So if you’re looking at things like semiglutide, which is ozempic, you know, or you’re looking at tricepidide, you, know, any of those, this is kind of the next step forward. And there’s a couple of different things that you kind of have to come and know about this one that’s really kind of great. It’s the, if you’re wondering what it looks like, I’m currently running it every time that I, before I will recommend anything or work with anybody on specific stuff like GLP-1s, I’ll run them for eight to 12 weeks just to kind of see how they feel. It is not a, it’s an ethical thing for me. I don’t like to recommend stuff or talk about stuff that I don’t have personal experience with. So that’s kind of one of the main reasons I do it. This one, because I’ve run semiglutide, wasn’t a huge fan, didn’t like the way it made me feel. And it was a little bit more difficult to titrate. This one is really nice. So I based this one off of what I did last time, still running my 47-1s, still taking everything, lifting the same way. My, my strength has not diminished at all. It’s kind, maybe a touch. And I’m down about 10 pounds, eight to 10 pounds depending on what day I’m weighing, from about 12 days ago.
Dr. Matt Chalmers [00:01:39] Most of that I’m assuming is fat because one, I have much visibly, the visibility of the leanness, if that makes any sense. I look a lot leaner than I did two weeks ago. And I feel leaner. One of the big things is that I feel like there’s less visceral fat. Which is a big thing. So not a whole lot of, I haven’t had any real gastric issues, haven’t had any stomach aches or anything like that. So let’s kind of run into real quick. If you guys want to watch them, you’re doing a, like every Tuesday and Saturday, I’m doing some posts on just check-ins, like how it looks. And I think so you can go back and watch those and kind of watch the progression of fat loss. If you want to kind of check out a in-process experiment. So let’s run through what retitrutide is. So retitutide is a triple, kind of triple function. So it hits GLP-1 receptors, it hits GIP and it hits glucagon. So the difference in this one is that it not only helps kind of, it goes through the whole spectrum. So it helps activate glucagone, which is going to help create a little bit more. Regulation sugars, it’s going to help the liver kind of reset that and process that out. And in the process, I think that’s where you’re getting a lot of your non-hepatic, the statosis of the, you know, non-alcoholic fatty liver disease, this has been shown to start kind of winding that back, which is phenomenal from a health perspective, regardless of fat loss or weight loss or anything like that. Cleaning of the liver is extremely important to long-term health.
Dr. Matt Chalmers [00:03:21] So if that’s one of the things you’ve got, non alcoholic fatty liver disease. This is one of those things I would definitely look at. I want to work with somebody who knows what they’re doing on this one. The, one of the downsides to RETTA and some of this stuff is still like very seen very, very rarely, but it is something to watch out for is hyperglycemia. So one of these pathways that this happens to hit is the glucagon function, which means you’re probably going to utilize fat as a fuel source at a much higher rate. People are referring to it as a thermogenic effect. I don’t really like that term. It’s used enough that people know what a thermogenic means. So basically it’s going to increase your fat loss because it’s utilizing fat as a fuel source at a higher rate. So that’s fantastic. Now, one of the things you’ve got to worry about with this whole deal is that it can, and some people spike the glucose too much. So we can get hyper hyperglycemia issues. So if you’re going to run this, I would make sure that you either use CGM. Or just take, pull your blood every once in a while, get with something who understands the gluconeogenesis function. So while we’re on gluconeogensis, remember your body’s going to tear apart proteins in order to go through gluconeogensis. Yeah, it’s going use fat to process this and use it as a fuel source, which is fantastic, but it’s gonna need proteins to actually rip apart.
Dr. Matt Chalmers [00:04:38] So keep that in mind. If you don’t keep your protein levels up high enough, your body is going to rip apart your muscle tissue because your muscle tissues are the easiest access protein your body has. And it’s gonna, when your glucagon hits it, it’s going to be like, we kind of make some sugar, we make sugar out of protein. So watch your muscle mass. There’s a variety of different ways of tracking that metric. If you’re working with somebody who understands gluconeogenesis and understands how these things work, that shouldn’t be a problem. So that is, that is one thing to watch out for. Obviously, since it hits the GLP-1 receptors as well, so it kind of does everything that semiglutide and trisipatide do, but it does more. Since it hits those, you’re going to see a little bit of the, you know, delay in gastric emptying. So if you eat something or you drink a bunch of water or something like that, you feel like it just sits right here and you’re just like, oh, I feel like I have a brick in my chest. That’s kind of what’s going on. And so make sure, again, you are working with somebody who understands gastric empty function and how to remedy that and how to titrate around it and how make sure that that doesn’t become a problem. So that’s one of the issues. The other one is we still have same liver functionality.
Dr. Matt Chalmers [00:05:44] So we’re going to have issues with cholecystitis and things like that. So again, you have to support the liver. Okay, guys, when you do something and you ask the body to process something, go through a chemical reaction, you’d have to give it all of the chemicals it requires to do that chemical reaction or else it’s going to start either messing up or stealing nutrients from something else that you don’t want stolen. So you’re going to have to really understand that you have to raise these things up. So minerals, you got to get your minerals up. Methylated B6 is a big one. Any nutrition to the liver is going to be important. Now here’s the thing. Remember this, and I realize there’s lots of moving parts in this. It’s like you tell you guys to work with somebody who knows what they’re doing. If you’ve got a bad parasite infection, even a mild parasite infection, it’s reducing all of the nutrients your body has to use primarily. Secondarily, it’s. Creating chemicals potentially that is going to help clog up the liver. Well, if you’ve got parasitic issues and yeast issues and you’ve got processed food issues and bad fats issues, and you’re not doing, you don’t have the methylated B6, methylated two, you don’t have, you know, some of the folic acid stuff. If you don’t have all the chemicals your body is requiring, it’s going to start gumming up the works. And so that’s, that’s one of the reasons that we’re seeing liver issues for this.
Dr. Matt Chalmers [00:06:59] So, you, know, even injection site issues or what seem to like. Allergic, allergic reactions to these things, oftentimes because the liver got too dirty or too full up with junk. If you’re processing a giant amount of fat and your body is moving that fat out, you have to understand the pathway, the lipolytic pathway that the body is using to do this. If you don’t, you’re going to miss components. And that’s where we start to have issues. So, um, look, make sure you’re checking all the liver pathways. Uh, and then any detox function you also have to support kidneys, but. Uh, these things are pretty nice. Now they do have a six day half life, roughly six day, half life. So, uh, they’re kind of, that’s very beneficial. If you’re doing a one giant injection per week, um, I still am not a huge fan of that. I’m not saying that’s a bad way to do it. I’m saying that it’s wrong way to it. It’s just not the way I like to do. Um, so if you’re gonna do it where you do it, you know, every day type of thing, understand that there’s a six-day half life you’re going to have to do the math to figure out, okay. Over the course of seven days, right. How do I track the half life function of the primary injection? The first one you gave all the way through those seven days to figure out where your levels actually are at. So, you know, make sure that you’re at least factoring that in, if you’re going to do this. Um, it is probably. It is probably going to come out as the best option for type D diabetics. Um, it might even the might, might.
Dr. Matt Chalmers [00:08:31] Help with some of the type one diabetics who are producing a little bit of insulin, because it does increase insulin sensitivity, insulin production, insulin function. So it is possible that some of these people that we’re finding at the, you know, eight, nine, 10 years old, who all of a sudden they’re their pancreas just isn’t producing the insulin we need. We might be able to use this and some of those people to help boost that function. This is a might, this is something I’d like to see a research before everybody starts playing with it, but just keep that kind of in mind as this is an option that we can start looking at in the future. So hopefully someone’s going to do that research so they can figure out, you know, how to, how the best utilize that to reset liver function. But in older people who have type two diabetes, this would also be a really, really great option. Wait for the research, um, you know, work with somebody who knows what they’re doing on it, but it would be probably the best option for type two diabetics as well, because, you know, it helps, you know, increase insulin sensitivity. It helps increase functionality. And if you pair that with a really good diet, especially you pair it with the diet and exercise program, I think that this will be the, it’ll be substantially easier to help convert the, the insulin resistance issues that create type two diabetes and dementia. Into a process where we can start walking that back in.
Dr. Matt Chalmers [00:09:46] I would really like to see some research done on this with dementia because one of the main problems with dementia is insulin resistance. Your brain communicates with insulin. If your body is no longer sensitive to insulin, you can’t hear the insulin anymore. Well, then your brain’s not going to work very well. Now, if we do something to help radically increase insulin sensitivity, that could theoretically help push back on the symptomatology of dementia and maybe help us walk it back. So. Um, if I was going to be doing research with dementia patients, I would 100% want to look at using this as an option for treatment therapy. Um, it’s again, these things are great. They’re powerful, but here, remember this thing, anything strong enough to help is strong enough. So make sure you’re doing these things cautiously and you’re working with people who know what they’re doing. You’re taking your blood beforehand. You’re taken your blood afterwards. And, you know, if you’re, you have, if your diabetic, we have any issues with blood sugar control, get a CGM, watch, make sure you don’t have any, uh, any increase in, in glucose levels that we don’t want. The only other thing is, and we don, this is kind of the weird thing with red true type that we really see in other places is there’s been some research showing that there’s a higher instance of heart rate. Uh, which would kind of make sense if you’re, if you were going to kind of kick the metabolic function of the body up that everything would kind of come up, so heart rate would come up. Uh, if your going to need more oxygen, heart rate obviously comes up.
Dr. Matt Chalmers [00:11:10] So watch that whole socks, uh, kind of watch where the oxygen levels are and the heart rate are. That’s the thing typically what we’re seeing is that it kind of slowly ramps up to about the 20 call it the 24th week kind of stabilizes and then starts going to come to that down. So. If you guys have heart issues, if you guys have, you know, any blockages, you have anything like that, make sure that you’re, you’re working with someone who’s monitoring all those things. Um, this is also why, uh, titrating up slowly is a great idea. Um, you know, everyone’s body reacts a little differently to things, especially things that are new. We need to be very, very cautious with things that are new, um, because until you get a couple of million people who’ve used it for four or five years, you don’t really know where these problems may lie. Um, one of the things that everybody needs to recognize is that the vast majority of people are highly minerally deficient. And if you want to get into why that is just Google nutrients and food, mineral, mineral density and United States food, 2025 versus 1980, um, and you’ll see that we have substantially reduced, uh, minerals in our foods and your body runs on minerals.
Dr. Matt Chalmers [00:12:18] So if you start taking something that’s going to push out minerals, or in this case. Use up the minerals you have in the body, doing chemical processes. You can get a few increase your metabolism. You’re increasing the speed at which you do chemical processes, so instead of doing two or three an hour, you might be doing seven or eight. Those chemical processes require chemicals. And so you’ve got to make sure your nutrients are high. So all your methylated B vitamins, you’ve gotta make sure that you’ve got, you know, again, a good, clean source of protein. Collagen can work. So that’s, that’s a good option. Uh, you gotta make sure that you have all your minerals, all your vitamins, go, cook you 10, you know, all those things, because if your body runs out of stuff to use in this chemical reaction and goes, no, we’re doing this because the receptor site told us to do it. It’ll start stealing stuff from everywhere else in the body. You don’t really want that because then you end up with nutrient deficiencies, mineral deficiencies that create serious issues. Um, specifically, like one of the things that we see is that, uh, there’s some heart issues that derive from mineral deficiency. Um, there’s a bunch of them, so you can get electrical issues. So VTAC and ATAC, um, you can get, you know, issues with contraction function.
Dr. Matt Chalmers [00:13:31] So again, be very, very cautious of mineral function as you’re doing this. So this is a, this is one of the things I had problems with, with semi-glutide was we gave metabolic tools. To people who think the body runs on calories. Again, this is, there’s another reason why I get so pissy. When we go back to you, they’re like, Oh, the body runs in calories, calories in calories out. Yeah. Completely ignore 100% of the metabolic biochemistry and just talk about chemistry, calories. Cause that’s anyway. So if your doctor’s basing your function on calories, do not work with him on this. They don’t understand the metabolic, biochemistry. I’d be very, very, worried about it. Um, this is what we saw with semi-glutide. People weren’t making metal, uh, giving the increase in methylated B vitamins. Uh, people weren’t, you know, titrating out and telling these guys are quitting all the sugar and trash is that sugar and trash that we’re eating was actually increasing the muscle loss they had. Um, people aren’t monitoring muscle loss. People aren’t monitor hormone function. If you’re, if you’re going to go into a process like this, that could start damaging muscle tissue, you need to make sure that you’re giving your body the hormones that tells it to regenerate that muscle tissue.
Dr. Matt Chalmers [00:14:36] So if you use, you know. 20% of the protein you’re consuming to create, um, sugar. And then when you stop eating, your body goes up. We got to tear apart the muscle tissues. You need to make sure you’re giving your body not only the nutrients, not just protein, but the nutrients to create that tissue again, but you also give it to the drive. So make sure your testosterone is where they’re supposed to be. Um, you can use some of the different, if you’re a peptide fan, you can use of the other, uh, peptides for, uh to like create more. Naturally produce growth hormone and IGF one. Um, so that will be beneficial. Now here’s the cool thing that I really want to see. And I have not seen any research on this. I’m not making any statements. It’s just something I want to see later is if we’re increasing insulin sensitivity, insulin functionality. I want to see where it takes insulin like growth factor one for my sensitivity functionality. So for instance, um, what we see with BPC, BPC one five seven and TV 500 is that it actually increases the body’s ability to utilize and increase the sensitivity to growth hormone and IGF one, which is why it heals so amazing. Um, so I want to see how playing with the insulin functionality, making insulin receptors, uh, more functionality, more functional is going to do for muscle creation, muscle wasting, you know, bone density stuff, like those types of things. Cause I think that’s going to be really, really beneficial. Um, we’ll have to see on that.
Dr. Matt Chalmers [00:15:57] And I can get any positive negative claims on that one right now. I’m just excited to see where that one goes. Um, I would, it is out of the choices that are out, um, I think that we’re going to start seeing a big shift in the ratatouille type. Um, especially because, you know, the, if you’re using the, it was Zympic, it’s like 12, 1300 bucks a month. You can get this for between, you know, 150 and 300 bucks a month, you have some of the box will last you six, eight weeks. If, you know, if the person is using it, if a, if you’re doing a research project on it or experimental research project on it, um, you’ll see some of that. Um, the thing is, is that again, with anything don’t, don’t go off of, Ted was using X amount so I can use that. That’s not how the body works. Uh, make sure that you guys, anybody who’s going to try to do this or try to use it, or if you’re being, if you can be able to be in any research projects, um, which I hope you are, if you aren’t, get ahold of us. I’d love to hear about all the stories and studies. Um, make sure that the titration up the slow and that you’re monitoring for side effects, but, uh, this is one of the new peptides that’s out and, uh people have been asking about it. And so the way I do things is I’ll, I’ll read a whole bunch about it. And then I’ll talk to the guys who are using it, um, other docs.
Dr. Matt Chalmers [00:17:13] So they’re, you know, people who are in this field, uh, and then I’ll run it myself to see kind of how it all goes. Uh, I’ve run something glute side. It’s not terrible. Um, it’s not bad. It’s this one’s just easier. This one’s this, when I feel like it works a lot faster, works a lot better, um and the side effects, I can’t like, I haven’t felt anything like I felt with this glue type. So. Uh, come up to you guys. How you want to run it? If you guys want to run it, get with the guys, get your docs who know how to use it. And, uh, we’ll kind of see how it kind of goes, but kind of keep me abreast of the stuff you guys are seeing any questions you guys have on it. Um, the, this one’s kind of, this was kind of cool. This one’s the new one. I think this is going to be, I think, this, we’re going to see if people can use it properly. We’ll see less side effects and we’ll see more benefit from it. So, uh if you guys, any other questions, hit us up questions at ChalmersWellness.com or toss them in the chat, it’s like normal. You guys have a great day. Thanks for your time.
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